Mesothelioma - Brief intorduction

A rare malignant (cancer) tumor of the mesothelium (the layer of cells derived from the mesoderm lining the primitive body cavity. In the adult it becomes the epithelium (the layer of cells forming the epidermis of the skin and the surface of layer of mucous and serous membranes. epithelium serves the general functions of protection, absorption, secretion and specialized functions such as movement of germ cells and reception of stimuli. Its ability to regenerate is excellent and it may replace itself as frequently as every 24 hours.) covering the serous membranes.

Large mass of solid tissue obliterating pleural space associated with pleural effusion which is haemorrhagic shows large endothelial cells and requires repeated tapping.

The tumor may be single or multiple, and it is rare tumor and it is related with the exposure to asbestos. Many of these tumors are in fact peripheral carcinoma of bronchus.

Sign & symptoms:

mesothelioma that affects the pleura can give

chest wall pain

pleural effusion, or fluid surrounding the lung

shortness of breath

fatigue or anemia

wheezing, hoarseness,

or cough blood in the sputum (fluid) coughed up (hemoptysis)

In severe cases there may be hard mass,pneumothorax or collapse of lung and this diesease may develop secondary mestastasisThe x-ray findings are characteristic cascade appearance.Treatment :Single tumor - By local excision of rib with overlying muscles and underlying pleuraMultiple tumor- by pleurectomy (removal of pleura) and intrapleural radio-active agents or chemotherapy.